The order of cancer-driving mutations—genetic changes—plays an important role in whether tumors in the intestine can develop, new research reveals. These are the findings published on 3 December in ...

What happens to the thousands of intestinal cells that have tumour-initiating DNA mutations? A study in mouse models shows that most are eliminated by strong negative selection, but those that survive ...

A recent study has uncovered how specific genetic mutations in α2δ-1 and α2δ-3 proteins linked to autism spectrum disorders ...

A single microscopic change in our DNA can permanently alter how the brain is built, locking in developmental problems that ...

Scientists at Johns Hopkins Medicine say they have developed a computer model — dubbed quantitative fate mapping — that looks back in the developmental timeline to trace the origin of cells in a fully ...

Scientists at Johns Hopkins Medicine say they have developed a computer model - dubbed quantitative fate mapping - that looks back in the developmental timeline to trace the origin of cells in a fully ...

Researchers have discovered that mutations affect protein stability following remarkably simple rules. The discovery has profound implications for accelerating the development of new treatments for ...

Every organism is born with a few mutations in their genome that differ genetically from both of their parents. Such changes in an individual’s genetic code create the diversity that allows nature to ...

Debora S. Marks is in the Department of Systems Biology, Harvard Medical School, Boston, Massachusetts 02115, USA, and at the Broad Institute of Harvard and MIT, Cambridge, Massachusetts. However, in ...

Although previously thought to be neutral, research in yeast suggests that synonymous point mutations may have strongly nonneutral effects. A group of researchers from the University of Michigan (MI, ...

Alex Nguyen Ba receives funding from the Natural Sciences and Engineering Research Council of Canada. University of Toronto provides funding as a founding partner of The Conversation CA. University of ...

Discover interesting facts about how evolution works, the different patterns that can emerge from evolution, how quickly organisms can evolve, and whether evolution is a random or ordered process When ...