News Medical

Study measures viral antigen and inflammatory biomarkers in CSF of COVID-19 patients in relation to neurologic symptoms and disease severity

In a recent study published in Jama Network, researchers investigated the impact of coronavirus disease 2019 (COVID-19) on biomarkers in the cerebrospinal fluid (CSF). Study: Viral Antigen and ...
ALZFORUM

Study Finds Sex Influences CSF Tau Levels in ApoE4 Carriers

The apolipoprotein E4 (ApoE4) allele, the strongest known genetic risk factor for late-onset sporadic Alzheimer’s disease, puts women at higher risk for the disease than men, but how remains unclear.

Gain Therapeutics Announces Positive Results in Key Exploratory Endpoint from its Phase 1b Clinical Study of GT-02287 in People with Parkinson’s Disease

Results showed CNS target engagement with reduction in GCase substrate glucosylsphingosine (GluSph) in cerebrospinal fluid (CSF), a prespecified ...
ALZFORUM

Untapped Resource? New Study to Boost Acceptance of CSF Analysis

Cerebrospinal fluid (CSF) analysis has perhaps the strongest diagnostic and prognostic potential for Alzheimer disease to date, yet some think the field is not harnessing its full power because ...
Nature

Phase II study of cisplatin, ifosfamide, and irinotecan with rhG-CSF support in patients with stage IIIb and IV non-small-cell lung cancer

In the 1990s, a number of new chemotherapeutic agents such as the taxanes, vinorelbine, gemcitabine, and irinotecan were introduced into the management of advanced non-small-cell lung cancer (NSCLC).
Business Wire

Stoke Therapeutics Announces Positive Interim Safety, PK and CSF Exposure Data from the Phase 1/2a MONARCH Study of STK-001 in Children and Adolescents with Dravet Syndrome

– Results show that single doses of STK-001 up to 30mg and multiple doses of 20mg were well-tolerated with no safety concerns related to the study drug – – A trend toward a reduction in convulsive ...
ascopubs.org

Impact of a G-CSF Policy to Reduce Low-Value Care on Guideline Adherence and Mortality

The data for this retrospective observational study were obtained from the electronic health records (EHRs) of patients with colorectal cancer who received chemotherapy at Texas Oncology. The EHR ...
Nature

Phase I/II study of oral etoposide plus GM-CSF as second-line chemotherapy in platinum-pretreated patients with advanced ovarian cancer

Optimal treatment for patients with resistant ovarian cancer has not been standardised to date. The main goals of salvage therapy in these patients are maximisation of their disease-free survival, ...
TCTMD

G-CSF Shows Positive Safety, Efficacy Signals After STEMI in Preliminary Studies

NEW YORK, NY—Results from a pair of small, randomized studies suggest that using granulocyte-colony stimulating factor (G-CSF) to mobilize stem cells is safe and may improve long-term cardiac function ...
Business Wire

GM-CSF Knock-out CAR-T Study Published in Peer-Reviewed Journal Leukemia

CRISPR/Cas9-Mediated GM-CSF knock-out (GM-CSF ko) CAR-T cells demonstrate reduced apoptosis and enhanced in vivo anti-tumor activity in preclinical models Phase 3 SHIELD study utilizing lenzilumab to ...
FiercePharma

Teva Announces Successful Results of Phase III Study of Its Long-Acting G-CSF Product (Lipegfilgrastim) in Breast Cancer P

JERUSALEM--(BUSINESS WIRE)-- Teva Pharmaceutical Industries Ltd. (NASDAQ: TEVA) announced today that lipegfilgrastim (INN; internal code - XM22) achieved its primary endpoint of reducing the duration ...