Be statistically valid, reliable, and accurate, Be comparable across collection types; and Meet the minimum reliability threshold, as determined by statistical testing.

May 12, 2025 · In the United States, recent data show that rates of sexually transmitted infections (STIs) reached an all-time high in 2021 among both females and males, and all racial and ethnic groups. …

The more alcohol consumed, the greater the risk of cancer. 6,8-11 For certain cancers, like breast, mouth, and throat cancers, evidence shows that this risk may start to increase around one or fewer …

Dec 16, 2022 · HHS is deeply committed to improving the physical and mental health and well-being of every American as we work to address the evolving crisis. HHS continues to support science- and …

Nov 10, 2025 · Women have used HRT products for decades to relieve menopausal symptoms. However, their use plummeted in the early 2000s when the FDA applied boxed warnings following a …

Tobacco referenced in this fact sheet refers to commercial tobacco products and not to the sacred and traditional tobacco used by some American Indian communities for ceremonial or medicinal …

Statistical sampling draws a random sample from a collection of claims and extrapolates (in other words, projects) the results of the sample to the entire “universe” of claims. OMHA statistical sampling is …

The appropriate inquiry is whether there is a well-documented, statistically and clinically meaningful effect on a prospectively defined endpoint, not whether the endpoint was identified as primary or …

In principle, being able to detect a statistically significant difference in pairwise comparisons between doses is not necessary if a statistically significant trend (upward slope) across doses can be …

Executive Summary Reliable and accurate scientific information is a cornerstone of effective policy- and decision- making. The U.S. Department of Health and Human Services (HHS or the Department) …